The second analysis provides for a statistical comparison of comodulation between the client and the database. It is a statistical analysis, and is scaled with reference to standard deviations for database means at a given frequency band in a given state. A 2.0 standard deviation value, plus or minus, indicates a 95% probability of significant increase or decrease in comparison to the database.

The cross-correlation analysis shown below is from an early forties female with severe endogenous depression. This analysis disclosed a unique area of pre-frontal and frontal hyper-correlation (red & pink zones) during the eyes closed state. That is, instead of individual sites in this area showing maximal cross-correlation only with themselves, a group of adjacent sites defined a zone of atypically shared spatio-temporal modulation in the dominant frequency band. This finding has been confirmed in a SKIL group study now underway, and is consistent with findings using other imaging techniques in the study of depression. Other patterns of deviant comodulation have been identified also in relation to head injury, focal epilepsy, and psychophysiological complaints.